Humoral immune responses during asthma and influenza co-morbidity in mice
نویسندگان
چکیده
منابع مشابه
Induction of humoral immune responses and inhibition of metastasis in mice by a VEGF peptide-based vaccine
Objective(s): Blocking of vascular endothelial growth factor (VEGF) plays a pivotal role in inhibition of metastasis and is a target for development of anti-angiogenic agents. In this study, a peptide-based vaccine was designed and its potential for induction of humoral immune responses, generation of neutralizing antibodies, inhibition of tumor growth and metastasis w...
متن کاملHumoral immune responses in CD40 ligand-deficient mice
Individuals with X-linked hyper-IgM syndrome fail to express functional CD40 ligand (CD40L) and, as a consequence, are incapable of mounting protective antibody responses to opportunistic bacterial infections. To address the role of CD40L in humoral immunity, we created, through homologous recombination, mice deficient in CD40L expression. These mice exhibited no gross developmental deficiencie...
متن کاملCellular and humoral immune responses during intrathoracic paracoccidioidomycosis in BALB/c mice.
Paracoccidioidomycosis is a chronic infection that primarily affects the lungs. Here we investigated cellular and humoral immune responses after intrathoracic Paracoccidioidesbrasiliensis infection in BALB/c mice. P. brasiliensis-colony-forming units (CFUs), fungal DNA and granulomas in lungs increased progressively, peaking at day 90 postinfection (p.i.). IFN-gamma production was highest on da...
متن کاملMHC IIB Genetic Diversity and its Association With Humoral Immune Responses in Commercial Turkey
Background: Major histocompatibility complex (MHC) is one of the best characterized genetic regions controlling immune responses against vaccines. Identifying the association between MHC haplotypes and improved immune responses would be useful in genetic breeding strategies in animals. OBJECTIVES: MHC class II B genetic diversity and its association with humoral immune responses against Newcast...
متن کاملpseudomonas aeruginosa recombinant flagellin induced poly-isotypic humoral immune responses in the balb/c mice
conclusions our results demonstrated that r-fla-a could induce cellular and humoral immune response as proper stimulant of poly-isotypic humoral responses. results immunized mice with adjuvanted flagellin showed a considerably increased lymphocyte proliferation compared with the control group (p = 0.004). high level of il-4 and ifn-γ secretion was observed in immunized mice compared with the co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunobiology
سال: 2017
ISSN: 0171-2985
DOI: 10.1016/j.imbio.2017.08.002